Vasso Apostolopoulos, PhD Professor

Email: vasso@scientist.com


    Vasso Apostolopoulos - Publications
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2011, In the Lab
2011, Visiting PhD Students from Victoria University
2011, Visiting PhD Student, Dr Nasir Eslami, from Institute Pasteur, Iran
2007, Lab Meeting
2006, Lab Meeting
2011, PostDoc Dr Stephanie Day
Apostolopoulos, V., Xing, P.X., Trapani, J.A. and McKenzie, I.F.C. Production of anti-breast cancer monoclonal antibodies using a glutathione-S-transferase-MUC1 bacterial fusion protein. British Journal of Cancer, 67:713-720, 1993. 

Xing, P.X., Apostolopoulos, V., Prenzoska, J., Devine, P.L. and McKenzie I.F.C. Peptide binding sites recognised by anti-mucin (MUC2) monoclonal antibodies. Scandinavian Journal of Immunology, 38:591-592, 1993. 

Apostolopoulos, V., Xing, P.X. and McKenzie, I.F.C. Murine immune response to cells transfected with human MUC1: immunisation with cellular and synthetic antigens. Cancer Research, 54:5186-5193, 1994. 

McKenzie, I.F.C., Apostolopoulos, V., Xing, P.X., Pietersz, G.A., Acres, B., Michaels, M., and Bishop, J. The immunogenicity of MUC1 peptides and fusion protein. International Journal of Oncology, I-12, 5:361-362, 1994 

Apostolopoulos, V., Pietersz, G.A., Xing, P.X., Lees, C., Michaels, M., Bishop, J. and McKenzie, I.F.C. The immunogenicity of MUC1 peptides and fusion protein. Cancer Letters, 90:21-26, 1995. 

Xing, P.X., Apostolopoulos, V., Michaels, M., Prenzoska, J., Bishop, J. and McKenzie, I.F.C. Phase I study of synthetic MUC1 peptides in cancer. International Journal of Oncology, 6:1283-1289, 1995. 

Apostolopoulos, V., Xing, P.X. and McKenzie, I.F.C. Anti-peptide monoclonal antibodies to intestinal Mucin 3. Journal of Gastroenterology and Hepatology, 10:555-561,1995. 

Apostolopoulos, V., Pietersz, G.A., Loveland, B.E., Sandrin, M.S. and McKenzie, I.F.C. Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses. Proceedings of the National Academy of Science USA, 92:10128-10132, 1995. 

Apostolopoulos, V., Loveland, B.E., Pietersz, G.A. and McKenzie, I.F.C. CTL in mice immunised with human Mucin 1 are MHC-restricted. Journal of Immunology, 155:5089-5094, 1995.

Apostolopoulos, V., Pietersz, G.A. and McKenzie, I.F.C. Cell-mediated immune responses to MUC1 fusion protein coupled to mannan. Vaccine, 14:930-938, 1996. 

Apostolopoulos, V., Haurum, J.S. and McKenzie, I.F.C. MUC1 peptide epitopes associated with 5 different H2 Class I molecules. European Journal of Immunology, 27:2579-2587, 1997. 

Lofthouse, S.A., Apostolopoulos, V., Pietersz, G.A. and McKenzie I.F.C. Induction of T1 (CTL) and/or T2 (antibody) response to a mucin-1 tumour antigen. Vaccine, 15:1586-1593, 1997. 

Xing, P.X., Prenzoska, J., Apostolopoulos, V., Karkaloutsos, J. and McKenzie, I.F.C. Monoclonal antibodies to a MUC4 peptide react with lung cancer. International Journal of Oncology, 11:289-295, 1997. 

Apostolopoulos, V., Karanikas, V., Haurum, J. and McKenzie, I.F.C. Induction of HLA-A2 Restricted Cytotoxic T Lymphocytes to the MUC1 Human Breast Cancer Antigen. Journal of Immunology, 159:5211-5218, 1997. 

Karanikas, V., Hwang, L., Pearson, J., Ong, C.S.,  Apostolopoulos, V., Vaughan, H., Xing, P.X., Jamieson, G., Pietersz, G.A., Tait, B., Broadbent, R., Thyme, G. and McKenzie, I.F.C. Antibody and T cell responses of patients with adenocarcinoma immunised with mannan-MUC1 fusion protein. Journal of Clinical Investigation, 100:2783-2792, 1997. 

McKenzie I.F.C., Apostolopoulos, V., Lees, C.J., Xing, P.X., Lofthouse, S.A., Osinski, C., Popovski, V., Acres, B. and Pietersz, G.A. Oxidised mannan antigen conjugates preferentially stimulate T1-type immune responses. Veterinary Immunology and Immunopathology, 63:185-190, 1998. 

Apostolopoulos, V., Popovski, V. and McKenzie, I.F.C. Cyclophosphamide enhances the CTL precursor frequency in mice immunised with MUC1-mannan fusion protein (M-FP). Journal of Immunotherapy, 21:109-113, 1998. 

Apostolopoulos, V., Lofthouse, S.A., Popovski, V., Chelvanayagam, G., Sandrin, M.S. and McKenzie I.F.C. Peptide mimics of a tumour antigen induce functional cytotoxic T cells. Nature Biotechnology, 16:276-280, 1998. [Comment in, 16:236-237, 1998]. 

Apostolopoulos, V., Osinski, C. and McKenzie I.F.C. MUC1 cross-reactive Gala(1,3)Gal antibodies in humans switch immune responses from cellular to humoral. Nature Medicine, 4:315-320, 1998. [Comment in, 4:270, 1998]. 

Apostolopoulos, V., Chelvanayagam, G., Xing, P.X. and McKenzie, I.F.C. Anti-MUC1 antibodies react directly with MUC1 peptides presented by class I H2 and HLA molecules. Journal of Immunology, 161:767-775, 1998. PDF

Pietersz, G.A., Wenjun, L., Popovski, V., Caruana, J-A., Apostolopoulos, V. and McKenzie, I.F.C. Parameters in using mannan-fusion protein (M-FP) to induce cellular immunity. Cancer Immunology Immunotherapy, 45:321-326, 1998. 

Apostolopoulos, V., Sandrin, M.S. and McKenzie, I.F.C. Mimics and cross reactions of relevance to tumour immunotherapy. Vaccine, 18:268-275, 1999. [Corresponding author].

Apostolopoulos, V., Sandrin, M.S. and McKenzie, I.F.C. Carbohydrate/peptide mimics: effect on MUC1 cancer immunotherapy. Journal of Molecular Medicine, 77:427-436, 1999. [Corresponding author].

Lees, C.J., Apostolopoulos, V. and McKenzie, I.F.C. Cytokine production from murine CD4 and CD8 cells after mannan-MUC1 immunization. Journal of Interferon Cytokine Research, 19:1373-1379, 1999. 

Lees, C.J., Apostolopoulos, V., Acres, B.A., Ong, C-S., Popovski, V. and McKenzie, I.F.C. The Effect of T1 and T2 cytokines on the cytotoxic T cell response to mannan-MUC1. Cancer Immunology Immunotherapy, 48:644-652, 2000. 

Acres, B., Apostolopoulos, V., Balloul, J.M., Wreschner, D., Xing, P.X., Hadji, D.A., Bizouarne, N., Kieny, M.P and McKenzie, I.F.C. MUC1 specific cytotoxic T cell precursor analysis in human MUC1 transgenic mice immunised with human MUC1 vaccines. Cancer Immunology Immunotherapy, 48:588-594, 2000. 

Lees, C.J., Apostolopoulos, V., Acres, B.A., Ramshaw, I., Ramsay, A., Popovski, V., Ong, C-S. and McKenzie, I.F.C. Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice. Vaccine, 19:158-162, 2000. 

Pietersz, G.A., Li, W., Osinski, C., Apostolopoulos, V. and McKenzie, I.F.C. Definition of MHC-restricted CTL epitopes from non-variable number of tandem repeats sequence of MUC1. Vaccine, 18:2059-2071. 2000. 

Degano, M., Garcia, K.C., Apostolopoulos, V., Rudolph, M., Teyton, L. and Wilson, I.A. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. Immunity, 12:251-261, 2000. 

Corper, A.L., Stratmann, T., Apostolopoulos, V., Scott, C.A., Garcia, K.C., Kang, A., Wilson, I.A. and Teyton, L. A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. Science, 288:505-511, 2000. PDF

Apostolopoulos, V., Pietersz, G.A., Gordon, S., Martinez-Pomares, L. and McKenzie, I.F.C. Aldehyde - mannan antigen complexes target the MHC Class I antigen presentation pathway. European Journal of Immunology, 30:1714-1723, 2000. [Corresponding author].

Apostolopoulos, V., Barnes, N., Pietersz, G.A. and McKenzie, I.F.C. Ex vivo targeting of the macrophage mannose receptor generates anti-tumor CTL responses. Vaccine, 18:3174-3184, 2000. [Corresponding author].

Apostolopoulos, V., McKenzie, I.F.C., Lees, C.J., Matthaei, K. and Young, I. A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo. European Journal of Immunology, 30:1733-1739, 2000. [Corresponding author].

Gong, J., Apostolopoulos, V., Chen, D., Chen, H., Koido, S., Gendler, S.J., McKenzie, I.F.C. and Kufe, D. Selection and characterization of MUC1-specific CD8+ T cells from MUC1 transgenic mice immunized with dendritic-carcinoma fusion cells. Immunology 101:316-324, 2000. 

Stratmann, T., Apostolopoulos, V., Mallet-Designe, V., Corper, A.L., Scott, C., Wilson, I.A., Kang, A. and Teyton, L. The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder. Journal of Immunology, 165:3214-3225, 2000. 

Pietersz, G.A., Li, W. and Apostolopoulos, V. A 16-mer peptide (RQIKIWFQNRRMKWKK) from antennapedia preferentially targets the Class I pathway. Vaccine, 19:1397-1405, 2001

Xing, P.X., Apostolopoulos, V., Pietersz, G.A. and McKenzie I.F.C. Anti-mucin monoclonal antibodies. Frontiers in Bioscience, 6D:1284-1295, 2001. 

Tselios T., Apostolopoulos, V., Daliani, I., Deraos, S., Grdadolnik, S., Mavromoustakos, T., Melachrinou, M., Thymianou, S., Probert, L., Mouzaki, A. and Matsoukas, J. Antagonistic effects of human cyclic MBP87-99 altered peptide ligands in experimental autoimmune encephalomyelitis and human T-cell proliferation. Journal of Medicinal Chemistry, 45:275-283, 2002. 

Lee, E.A.M., Palmer, D.R., Flanagan, K.L., Reece, W.H.H., Odhiambo, K., Marsh, K., Pinder, M., Gravenor, M.B., Keitel, W.A., Kester, K.E., Diggs, C., Kaslow, D., Apostolopoulos, V., Ballou, W.R., Hill, A.V.S., Krzych, U. and Plebanski, M. Induction of T helper type 1 and 2 responses to 19kDa Merozoite Surface Protein-1 in vaccinated healthy volunteers and adults naturally exposed to malaria. Infection and Immunity, 70:1417-1421, 2002. 

Luz, J.G., Huang, M., Garcia, K.C., Rudolph, M.G., Apostolopoulos, V., Teyton, L. and Wilson, I.A. Structural comparison of allogeneic and syngeneic TCR-peptide-MHC complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) interactions. Journal of Experimental Medicine, 195:1175-11186, 2002. 

Apostolopoulos, V., Yu, M., Corper, A.L., Teyton, L., Pietersz, G.A., McKenzie, I.F.C. and Wilson, I.A. Crystal structure of a non-canonical low affinity peptide complexed with MHC class I: a new approach for vaccine design. Journal of Molecular Biology 318:1293-1305, 2002. [Corresponding author].

Apostolopoulos, V., Yu, M., Corper, A.L., Li, W., McKenzie, I.F.C., Teyton, L. and Wilson, I.A. Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors. Journal of Molecular Biology 318:1307-1316, 2002. [Corresponding author].

Plebanski, M., Proudfoot, O., Pouniotis, D., Coppel, R.L., Apostolopoulos, V. and Flannery, G. Immunogenetics and the design of Plasmodium falciparum vaccines for use in malaria endemic populations. Journal of Clinical Investigation, 110:295-301, 2002. 

Davis, W.C., Konzek, R.L., Haas, K., Estes, D.M., Hamilton, M.J., Call, D.R., Apostolopoulos, V. and McKenzie, I.F.C. Use of the mannan receptor to selectively target vaccine antigens for processing and antigen presentation through the MHC class I and class II pathways. Annals of NY Academy of Science, 969:119-125, 2002. 

Apostolopoulos, V., Yuriev, E., Ramsland, P.A., Plebanski, M., Paulsen, H. and McKenzie, I.F.C. A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor. Proceedings of the National Academy of Science, USA, 100:15029-15034, 2003. Corresponding author]. PDF

Wright, M.D., Geary, S.M., Fitter, S., Moseley, G., Lau, L-M., Sheng, K-C., Apostolopoulos, V., Stanley, E., Jackson, D.E. and Ashman, L.K. Characterisation of mice lacking the tetraspanin superfamily member CD151. Molecular Cellular Biology, 24:5978-5988, 2004.

Pouniotis, D.S., Proudfoot, O., Bogdanoska, V., Apostolopoulos, V., Fifis, T. and Plebanski, M. Dendritic cells induce immunity and long-lasting protection against blood-stage malaria despite an in vitro parasite induced maturation defect. Infection and Immunity, 72:5331-5339, 2004. 

Schuman, J.T., Grinstead, J.S., Apostolopoulos, V. and Campbell, A.P. Structural and dynamical consequences of increasing repeats in a MUC1 peptide tumour antigen. Biopolymers, 77:107-120, 2005. 

Matsoukas, J., Apostolopoulos, V., Kalbacher, H., Papini, A.M., Tselios, T., Chantzantoni, K., Biagioli, T., Lolli, F., Deraos, S., Papathanassopoulos, P., Troganis, A., Mantzourani, E., Mavromoustakos, T. and Mouzaki, A. Design and synthesis of a novel potent myelin basic protein epitope MBP87-99 cyclic analogue: Enhanced stability and biological properties of mimics render them a potentially new class of Immunomodulators. Journal of Medicinal Chemistry, 48:1470-1480, 2005. 

Plebanski, M., Hannan, C.M., Behboudi, S., Flanagan, K.L., Apostolopoulos, V., Sinden, R.E. and Hill, A.V.S. Direct processing and presentation of antigen from malaria sporozoites by professional antigen presenting cells in the induction of CD8+ T cell responses. Immunology and Cell Biology, 83:307-312, 2005. 

Tselios, T., Lamari, F.N., Karathanasopoulou, I., Katsara, M., Apostolopoulos, V., Pietersz, G.A., Matsoukas, J. and Karamanos, N.K. Synthesis and study of the electrophoretic behavior of mannan conjugates with cyclic peptide analogue of myelin basic protein using lysine-glycine linker. Analytical Biochemistry, 347:121-128, 2005. 

Pouniotis, D.S., Pietersz, G.A.* and Apostolopoulos, V*. Penetratin tandemly linked to a CTL peptide induces anti-tumour T cell responses via a cross-presentation pathway. Immunology, 117:329-339, 2006. (*equal contribution) [Corresponding author].

Pouniotis, D.S., Plebanski, M., McDonald, C.* and Apostolopoulos, V*. Alveolar macrophage function is altered in patients with lung cancer. Clinical and Experimental Immunology, 143:363-372, 2006. (*equal contribution). [Corresponding author].

Loveland, B.E., Zhao, A., White, S., Gan, H., Hamilton, K., Xing, P-X., Pietersz, G.A., Apostolopoulos, V., Vaughan, H., Karanikas, V., Kyriakou, P., McKenzie, I.F.C. and Mitchell, P.L.R. Mannan-MUC1 pulsed dendritic cell immunotherapy: a phase I trial in patients with adenocarcinoma. Clinical Cancer Research, 12:869-877, 2006.

Apostolopoulos, V., Pouniotis, D.S., van Maanen, JP., Andriessen, R., Lodding, J., Xing, P.X., McKenzie, I.F.C., Loveland B.E. and Pietersz, G.A. Delivery of tumour associated antigens to antigen presenting cells using penetratin induces potent immune responses. Vaccine, 24:3191-3202, 2006. [Corresponding author].

Sheng, K-C., Pouniotis, D.S., Wright, M.D., Tang, C.K., Lazoura, E., Pietersz, G.A. and Apostolopoulos, V. Mannan derivatives induce phenotypic and functional maturation of mouse dendritic cells., 118:372-383, 2006. [Corresponding author].

Apostolopoulos, V., Pietersz, G.A., Tsibanis, A., Tsikkinis, A., Drakaki, H., Loveland, B.E., Piddlesden, S.J., Plebanski, M., Pouniotis, D.S., Alexis, M.N., McKenzie, I.F.C. and Vassilaros, S. Pilot Phase III immunotherapy study in early stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]. Breast Cancer Research, 8:R27-38, 2006. [Corresponding author; Highly accessed article; article highlight in the month of July at journal website].

Xiang, S.D., Scholzen, A., Minigo, G., David, C., Apostolopoulos, V., Mottram, P. and Plebanski, M. Pathogen recognition and development of particulate vaccines: does size matter?. [Special issue on Particulate Vaccines]. Methods, 40:1-9, 2006 

Lazoura, E., Lodding, J., Farrugia, W., Ramsland, P.A., Stevens, J.E., Wilson, I.A., Pietersz, G.A. and Apostolopoulos, V. Enhanced class I binding and immune responses through anchor modification of the non-canonical tumour associated MUC1-8 peptide. Immunology, 119:306-316, 2006. [Corresponding author; article highlight in the months of Sept-Nov at journal website]. PDF

Enomoto, Y., Bharti, A., Khaleque, A.A., Song, B., Liu, C., Apostolopoulos, V., Xing, P.X., Calderwood, S. and Gong, J. Enhanced immunogenicity of HSP70 peptide complexes from DC-tumour fusion cells. Journal of Immunology, 177:5946-5955, 2006.

Minigo, G., Scholzen, A., Tang, C.K., Hanley, J.C., Kalkanidis, M., Pietersz, G.A., Apostolopoulos, V. and Plebanski, M. Poly-L-lysine-coated nanoparticles: a potent delivery system to enhance DNA vaccine efficacy. 25:1316-1327, Vaccine, 2007. 

Tang, C.K., Lodding, J., Minigo, G., Pouniotis, D.S., Plebanski, M., Scholzen, A., McKenzie, I.F.C., Pietersz, G.A. and Apostolopoulos, V. Mannan mediated gene delivery for cancer immunotherapy. Immunology, 120:325-335, 2007. [Corresponding author; article highlight in the months of January-February at journal website]. PDF

Sheng, K.C., Kalkanidis, M., Pouniotis, D.S., Esparon, S., Tang, C.K., Apostolopoulos, V., and Pietersz, G.A. Delivery of antigen using novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivo. European Journal of Immunology, 38:424-436, 2008. 

Sheng, K.C., Kalkanidis, M., Pouniotis, D.S., Pietersz, G.A. and Apostolopoulos, V. The adjuvanticity of a mannosylated antigen reveals toll-like receptor 4 functionality essential for subset specialisation and functional maturation of mouse dendritic cells. Journal of Immunology, 181:2455-2464, 2008. [Corresponding author].

Katsara, M., Yuriev, E., Ramsland, P.A., Deraos, G., Tselios, T., Matsoukas, J. and Apostolopoulos, V. Mannosylation of MBP83-99 peptides diverts immune responses from Th1 to Th2. Molecular Immunology, 45:3661-3670, 2008. [Corresponding author].

Katsara, M., Deraos, G., Tselios, T., Matsoukas, J. and Apostolopoulos, V. Design of novel altered peptide ligands of myelin basic protein MBP83-99 modulate immune responses in SJL/J mice. Journal of Medicinal Chemistry, 51: -3978, 2008. [Corresponding author].

Tang, C.K., Sheng, K-C., Pouniotis, D.S., Esparon, S., Son, H-Y., Kim, C-Y., Pietersz, G.A. and Apostolopoulos, V. Oxidised and reduced mannan mediated MUC1 DNA immunisation induce effective anti-tumour responses. Vaccine, 26:3827-3834, 2008. [Corresponding author]. PDF

Katsara, M., Yuriev, E., Ramsland, P.A., Deraos, G., Tselios, T., Matsoukas, J. and Apostolopoulos, V. A double mutation of MBP83-99 peptide induces IL-4 responses and antagonizes IFN-g responses. Journal of Neuroimmunology, 200:77-89, 2008. [Corresponding author].

Deraos, G., Chatzantoni, K., Matsoukas, M-T., Katsara, M., Tselios, T., Deraos, S., Papathanasopoulos, P., Vynios, D., Mouzaki, A*., Matsoukas, J*. and Apostolopoulos, V*. Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP87-99) epitope elicits a Th1 polarized responses by T cells isolated from multiple sclerosis patients: implications in triggering disease. Journal of Medicinal Chemistry, 51(24):7834-7842, 2008. (*equal contribution). [Corresponding author].

Katsara, M., Deraos, G., Tselios, T., Matsoukas, M-T., Friligou, M., Matsoukas, J. and Apostolopoulos, V. Design and synthesis of a cyclic double mutant peptide (cyclo(87-99)[A91,A96]MBP87-99) induces altered responses in mice after conjugation to mannan: implications in the immunotherapy of MS. Journal of Medicinal Chemistry, 52(1):214-218, 2009 [Corresponding author].

Tang, C.K., Sheng, K-C., Esparon, S., Pietersz, G.A*. and Apostolopoulos, V*. Molecular basis of improved immunogenicity in DNA vaccination mediated by a mannan based carrier. Biomaterials, 30:1389-1400, 2009. (*equal contribution). PDF

Sheng, K.C., vanSpriel, A.B., Gartlan, K., Sofi, M., Apostolopoulos, V., Ashman, L. and Wright, M.D. Tetraspanins CD37 and CD151 differentially regulate antigen presentation and T cell co-stimulation by dendritic cells. European Journal of Immunology, 39(1):50-55, 2009. 

Lazoura, E., Lodding, J., Farrugia, W., Day, S., Ramsland, P.A. and Apostolopoulos, V. Non-Canonical anchor motif peptides bound to MHC class I induce cellular responses. Molecular Immunology, 46:1171-1178, 2009. [Corresponding author].

Katsara, M., Yuriev, E., Ramsland, P.R., Tselios, T., Deraos, G., Lourbopoulos, A., Grigoriadis, N., Matsoukas, J. and Apostolopoulos, V. Altered peptide ligands of myelin basic protein (MBP87-99) conjugated to reduced mannan modulate immune responses in mice. Immunology, 128(4):521-533, 2009 [Corresponding author].

Gong, J., Zhang, Y., Durfee, J., Koide, T., Weng, D., Liu, C., Koido, S., Song, B., Apostolopoulos, V., and Calderwood, S.K. An HSP-70-based vaccine with enhanced immunogenicity for clinical use. Journal of Immunology, 184:488-496, 2010. 

Sheng, K.C., Pietersz, G.A., Tang, C.K., Ramsland, P.A. and Apostolopoulos, V. Reactive oxygen species level defines two functionally distinctive stages of inflammatory DC development from mouse bone marrow. Journal of Immunology, 184(6):2863-2872, 2010. [Corresponding author].

Laimou, D.K., Katsara, M., Matsoukas, M-T., Apostolopoulos, V., Troganis, A.N. and Tselios, T. Structural elucidation of Leuprolide and its analogues in solution: insights into their bioactive conformation. Amino Acids, 39(5):1147-1160, 2010. 

Brooks, N.A., Pouniotis, D.S., Sheng, K.C., Apostolopoulos, V. and Pietersz, G.A. A membrane penetrating multiple antigen peptide (MAP) incorporating ovalbumin CD8 epitope induces potent immune responses in mice. Biochim Biophys Acta – Biomembranes, 1798(12):2286-2295, 2010. 

Gartlan, K.H., Belz, G.T., Tarrant, J.M., Minigo, G., Katsara, M., Sheng, K-C., Sofi, M., van Spriel, A.B., Apostolopoulos, V., Plebanski, M., Robb, L. and Wright, M.D. A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. Journal of Immunology, 185(6):3158-3166, 2010. 

Stavrakoudis, A., Tsoulos, I.G., Uray, K., Hudecz, F. and Apostolopoulos, V. Homology modelling and molecular dynamics simulations of MUC1-9/H-2Kb complex suggests novel binding interactions. Journal of Molecular Modeling, 17(7):1817-1829, 2010. [Corresponding author].

Plebanski, M., Katsara, M., Sheng, K.C., Xiang, S. and Apostolopoulos, V. Methods to measure T cell responses. Expert Review of Vaccines, 9(6):595-600, 2010. [Corresponding author]. Ranked Number 1 from 2010-December 2012 as assessed by BioMedLib (www.BioMedLib.com)

Wilkinson, B.L., Day, S., Malins, L.R., Apostolopoulos, V. and Payne, R.J. Self-adjuvanting multicomponent cancer vaccine candidates combining per-glycosylated MUC1 glycopeptides and the Toll-like receptor 2 agonist Pam3CysSer. Angewandte Chemie, International Edition, 50(7): 1635-1639, 2011. 

Pouniotis, D.S., Esparon, S., Apostolopoulos, V. and Pietersz, G.A. Whole protein and defined CD8+ and CD4+ peptides linked to penetratin targets both MHC class I and II antigen presentation pathways. Immunology and Cell Biology, 89(8):904-913, 2011. 

Donkor, O., Ravikumar, M., Proudfoot, O., Day, S.L., Apostolopoulos, V., Paukovics, G., Vasiljevic, T., Nutt, S., Gill, H. Cytokine profile and induction of Th17 and Treg cells by human peripheral mononuclear cells after microbial exposure. Clinical and Experimental Immunology, 167(2):282-295, 2012. 

Laimou, D., Lazoura, E., Troganis, A.N., Matsoukas, M-T., Deraos, S.N., Katsara, M., Matsoukas, J., Apostolopoulos, V. and Tselios, T. Conformational studies of immunodominant myelin basic protein 1-11 analogues using NMR and molecular modelling. Journal of Computer-aided Molecular Design, 25(11):1019-1032, 2011. 

Eslami, N.S., Shokrgosar, M.A., Mousavi, A., Azadmanesh, K., Nomani, A., Apostolopoulos, V., Day, S., Amanzadeh, A. and Allmohammadian, M.H. Simultaneous immunisation with a Wilms tumour 1 epitope and its ubiquitin fusions results in enhanced cell mediated immunity and tumour rejection in C57BL/6 mice. Molecular Immunology, 51(3-4):325-331, 2012. 

Brooks, N., Stojanovska, L., Grant, P., Apostolopoulos, V., McDonald, C.F., and Pouniotis, D.S. Characterisation of blood monocytes phenotype in endometrial cancer patients. International Journal of Gynecological Cancer, 22(9):1500-1508, 2012. 

Wilkinson, B.L., Day, S., Chapman, R., Perrier, S., Apostolopoulos, V. and Payne, R.J. Synthesis and immunological evaluation of self-assembling and self-adjuvanting tri-component glycopeptide cancer vaccine candidates. Chemistry: A European Journal, 18(51):16540-16548, 2012. 

Gartlan, K.H., Wee, J.L., DeMaria, M.C., Nastovska, R., Chang, T.M., Jones, E.L., Apostolopoulos, V., Pietersz, G.A., Hickey, M.J., van Spriel, A.B. and Wright, M.D. Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration. European Journal of Immunology, 43(5):1208-1219, 2013. PDF

Sheng, K.C., Day, S., Wright, M.D., Stojanovska, L. and Apostolopoulos, V. Enhanced dendritic cell-mediated antigen-specific CD4+ T cell responses: IFN-gamma aids TLR stimulation. Journal of Drug Delivery, Volume 2013, Article ID 516749, Epub May 28 2013. [Corresponding author]. PDF

Tian, D.H., Perera, C.J., Apostolopoulos, V. and Moalem-Taylor, G. Effects of vaccination with altered peptide ligand on chronic pain in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Frontiers in Neurology – Multiple Sclerosis and Neuroimmunology. 4(168):1-8, 2013. PDF

Vassilaros, S., Tsibanis, A., Tsikkinis, A., McKenzie, I.F.C. and Apostolopoulos, V. Up to 15 year clinical follow-up of pilot phase III immunotherapy study in stage II breast cancer patients using oxidised mannan-MUC1. Immunotherapy, 5(11):1177-1182, 2013. PDF


7 Research Publications, Submitted 
13 Research Publications, In Preparation


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RESEARCH PUBLICATIONS
REVIEWS
Apostolopoulos, V., Xing, P.X. and McKenzie, I.F.C. New trends in the development of a breast cancer vaccine. Cancer Forum: Immunotherapy - Research and Clinical Status, 17:111-116, 1993. 

Apostolopoulos, V. and McKenzie, I.F.C. Cellular Mucins - Targets for Immunotherapy. Critical Reviews in Immunology, 14:293-309, 1994. 

Apostolopoulos, V., McKenzie, I.F.C. and Pietersz, G.A. Breast cancer immunotherapy - Current status and future prospects. Immunology and Cell Biology, 74:457-464, 1996. [Nature publishing group]. 

Chelvanayagam, G., Apostolopoulos, V. and McKenzie, I.F.C. Milestones in the molecular structure of the major histocompatibility complex. Protein Engineering, 10:471-474, 1997.

Apostolopoulos, V., Sandrin, M.S. and McKenzie, I.F.C. Cross reactive antibodies deviate immune responses from cellular to humoral. Biotech Lab International, 11/12, 1998. 

Apostolopoulos, V., Pietersz, G.A. and McKenzie, I.F.C. MUC1 and breast cancer. Current Opinion in Molecular Therapeutics 1:98-103, 1999. [Invited review. Corresponding author]

McKenzie, I.F.C. and Apostolopoulos, V. Towards immunotherapy of pancreatic cancer. Gut (Leading article), 44:767-769, 1999. 

Apostolopoulos, V., Yu, M., McKenzie, I.F.C. and Wilson, I.A. Structural implications of the design of molecular vaccines. Current Opinion in Molecular Therapeutics, 2:29-36, 2000. [Invited review. Corresponding author].

McKenzie, I.F.C. and Apostolopoulos, V. Towards immunotherapy for pancreatic cancer. Gut (Letter to the Editor, Reply), 46:582-583, 2000.

Teyton, L., Apostolopoulos, V., Cantu, C III., Celia, H., Designe-Mallet, V., Stefanko, R., Stratmann, T. and Wallace, M. Function and Dysfunction of the T cell receptor: Structural studies. Immunologic Research, 21:325-330, 2000

Pietersz, G.A., Apostolopoulos, V. and McKenzie, I.F.C. Generation of cellular immune responses to antigenic tumor peptides. Cellular and Molecular Life Sciences, 57:290-310, 2000

Apostolopoulos, V. and Plebanski, M. The evolution of DNA vaccines. Current Opinion in Molecular Therapeutics. 2:441-447, 2000. [Invited review. Corresponding author].

Matsoukas, J., Apostolopoulos, V. and Mavromoustakos, T. Designing peptide mimetics for the treatment of multiple sclerosis. Mini Reviews in Medicinal Chemistry, 1:273-282, 2001. 

Mavromoustakos, T., Apostolopoulos, V. and Matsoukas, J. Antihypertensive drugs that act on Resin-Angiotensin system with emphasis in AT1 antagonists. Mini Reviews in Medicinal Chemistry, 1:207-217, 2001. 

Apostolopoulos, V. and McKenzie, I.F.C. Role of the mannose receptor in the immune response. Current Molecular Medicine, 1:457-462, 2001. [Invited review. Corresponding author].

Apostolopoulos, V., McKenzie, I.F.C. and Wilson, I.A. Getting into the groove: Unusual features of peptide binding to MHC class I molecules and implications in vaccine design. Frontiers in Bioscience, 6D:1311-1320, 2001. [Invited review. Corresponding author]

Apostolopoulos, V., Matsoukas, J., Plebanski, M. and Mavromoustakos, T. Applications of peptide mimetics in cancer. Current Medicinal Chemistry, 9:411-420, 2002. [Invited review. Corresponding author]

McKenzie, I.F.C., Apostolopoulos, V., Plebanski, M., Pietersz, G.A and Loveland, B.E. Aspects of Cancer Immunotherapy. Immunology and Cell Biology 81:79-85, 2003 [Nature publishing group]. 

Pouniotis, D., Plebanski, M. and Apostolopoulos, V. Up or Down - On or Off: Altered peptide ligands in disease. Research Advances in Medicinal Chemistry 1:1-10, 2004. [Invited review. Corresponding author].

Apostolopoulos, V. and Lazoura, E. Non-canonical peptides in complex with MHC class I. Expert Review of Vaccines. 3:151-162, 2004. [Invited review. Corresponding author].

Minigo, G., Plebanski, M. and Apostolopoulos, V. Altered peptide ligand antagonism: From immune evasion to immunotherapy. Drug Design Reviews, 1:145-151 2004. [Invited review. Corresponding author].

Pouniotis, D.S., Halton, J. and Apostolopoulos, V. Peptide based vaccine design for cancer immunotherapy. Letters in Drug Design and Discovery, 1:203-210, 2004. [Invited review. Corresponding author].

Hu, X.F., Apostolopoulos, V. and Xing, P.X. Monoclonal antibodies and T cell immune responses to mucins and their peptides. Current Topics in Peptide and Protein Research, 6:177-188, 2004.

Apostolopoulos, V., C.K. Tang. and Pietersz, G.A. Non-Viral vector approaches towards gene delivery: Current status and future prospects. Current Trends in Immunology 6:21-37, 2004. [Invited review. Corresponding author]

Apostolopoulos, V., Hu, X.F., Pouniotis, D.S. and Xing, P.X. MUC1: a molecule of many talents. Current Trends in Immunology 6:39-55, 2004. [Invited review. Corresponding author]

Lazoura, E and Apostolopoulos, V. Rational peptide-based vaccine design for cancer immunotherapeutic applications. Current Medicinal Chemistry, 12:629-639, 2005. [Invited review. Corresponding author]

Lazoura, E and Apostolopoulos, V. Insights into peptide-based vaccine design for cancer immunotherapy. Special Issue – Bioactive Peptides in Immune Disease Therapy. Current Medicinal Chemistry, 12:1481-1494, 2005. [Invited review. Corresponding author].

Tzakos, A.G., Troganis, A., Theodorou, V., Tselios, T., Svarnas, C., Matsoukas, J., Apostolopoulos, V. and Gerothanassis, I.P. Structure and function of the Myelin proteins: Current status and perspectives in relation to multiple sclerosis. Special Issue – Bioactive Peptides in Immune Disease Therapy. Current Medicinal Chemistry, 12:1569-1587, 2005. 

Sheng, K-C., Pietersz, G.A., Wright, M.D. and Apostolopoulos, V. Dendritic cells: activation and maturation - application in therapy for cancer. Current Medicinal Chemistry, 12:1783-1800, 2005. [Invited review. Corresponding author]

Pietersz, G.A., Pouniotis, D.S. and Apostolopoulos, V. Design of peptide based vaccines for cancer. Current Medicinal Chemistry, 13:1591-1607, 2006. [Invited review. Corresponding author]

Sheng, K-C., Apostolopoulos, V., Wright, M.D. and Pietersz, G.A. Ligand-mediated dendritic cell activation. Current Trends in Immunology, 7:1-30, 2006.  

Katsara, M., Tselios, T., Deraos, S., Deraos, G., Matsoukas, M., Lazoura, E., Matsoukas, J. and Apostolopoulos, V. Round and round we go: cyclic peptides in disease. Current Medicinal Chemistry, 13:2221-2232, 2006 [Invited review. Corresponding author]

Scalzo, K., Plebanski, M. and Apostolopoulos, V. Regulatory T cells: immuno-modulators in health and disease. Current Topics in Medicinal Chemistry, 6:1759-1768, 2006. [Invited review. Corresponding author]

Pietersz, G.A., Tang, C.K. and Apostolopoulos, V. Structure and design of cationic carriers for gene delivery. Mini Reviews in Medicinal Chemistry, 6:1285-1298, 2006. [Invited review. Corresponding author]

Proudfoot, O., Apostolopoulos, V. and Pietersz, G.A. Receptor mediated delivery of antigens to dendritic cells: anticancer applications. Molecular Pharmaceutics, 4:58-72, 2007]. [Special issue on delivery systems for vaccines] [Invited. Corresponding author] [Most cited article as of March 31, 2008; http://pubs.acs/jounals/promo/most/most cited].

Tang, C.K. and Apostolopoulos, V. Strategies used for MUC1 immunotherapy – preclinical studies. Expert Review of Vaccines, (Special Focus issue on Cancer Vaccines), 7:951-962, 2008. [Invited review. Corresponding author]

Tang, C.K., Katsara, M. and Apostolopoulos, V. Strategies used for MUC1 immunotherapy - human clinical studies. Expert Review of Vaccines, (Special Focus issue on Cancer Vaccines), 7:963-975, 2008. [Invited review. Corresponding author]

Tang, C.K., Sheng, K.C., Apostolopoulos, V. and Pietersz, G.A. Protein/peptide and DNA vaccine delivery by targeting C-type lectin receptors. Expert Review of Vaccines, (Special Focus issue on Cancer Vaccines), 7:1005-1018, 2008. [Invited review].

Katsara, M., Matsoukas, J., Deraos, G. and Apostolopoulos, V. Towards immunotherapeutic drugs and vaccines against multiple sclerosis. Acta Biochimica et Biophysica Sinica, (Special 50th anniversary issue). 40:636-642, 2008. [Invited review. Corresponding author].

Apostolopoulos, V., Yuriev, E., Lazoura, E., Yu, M. and Ramsland, P.A. MHC and MHC-like molecules: structural perspectives for the design of molecular vaccines. Human Vaccines, 4(6):400-409, 2008. [Invited. Corresponding author].

Katsara, M., Minigo, G., Plebanski, M. and Apostolopoulos, V. The good, the bad and the ugly: How altered peptide ligands modulate immunity. Expert Opinion on Biological Therapy, 8(12):1873-1884, 2008. [Invited review. Corresponding author].

Day, S.L., Ramsland, P.R. and Apostolopoulos, V. Non-canonical peptides bound to MHC. Current Pharmaceutical Design, 15:3274-3282, 2009. [Invited review. Corresponding author]

Brooks, N.A., Pouniotis, D.S., Tang, C-K., Apostolopoulos, V. and Pietersz, G.A. Cell penetrating peptides: applications in vaccine delivery. Biochim Biophys Acta – Reviews on Cancer, 1805:25-34, 2010. 

Donkor, O.N., Shah, N.P., Apostolopoulos, V. and Vasiljevic, T. Development of allergic responses related to microorganisms exposure in early life. International Dairy Journal, 20:373-385, 2010

Xiang, S.D., Selomulya, C., Ho, J., Apostolopoulos, V. and Plebanski, M. Delivery of DNA vaccines: an overview on the use of biodegradable polymeric and magnetite nanoparticles. WIREs Nanomedicine and Nanobiotechnology, 2(3):205-218, 2010.

Sheng, K.C., Wright, M.D. and Apostolopoulos, V. Inflammatory mediators hold the key to dendritic cell suppression and tumour progression. Current Medicinal Chemistry, 18:5507-5518, 2011. [Invited review. Corresponding author]

Kong, Y.Y., Fuchsberger, M., Xiang, S.D., Apostolopoulos, V. and Plebanski, M. Myeloid-Derived Suppressor Cells and their role in diseases. Current Medicinal Chemistry, 20(11):1437-1444, 2013. [Corresponding author]. PubMed

Apostolopoulos, V., Thalhammer, T., Tzakos, A. and Stojanovska, L. Targeting antigens to dendritic cell receptors for vaccine development. Journal of Drug Delivery, Article ID869718, Epub October 2013. [Invited review, Corresponding author]. PDF

Stojanovska, L., Apostolopoulos, V., Polman, R. and Borkoles, E. To exercise, or, not to exercise, during menopause and beyond. Maturitas, 77(4):318-323, 2014. PDF


3 Reviews, Submitted
6 Reviews, In Preparation


                                                   ________________________ // ________________________

JOURNAL INTERVIEWS
Pouniotis, D.S., McDonald, C.S. and Apostolopoulos, V. Lung cancer and alveolar macrophage function. Modern Aspects of Immunobiology – Platform Journal (MAI-Interview), 20:2-3, 2006. [Invited. Corresponding author]

Apostolopoulos, V. News and Views. Cancer vaccines and immunotherapy of autoimmune diseases. Immunotherapy, 1(1):15-17, 2009. [Invited]

Apostolopoulos, V. Interview. Cancer Vaccines: Looking to the future. Expert Review of Vaccines, 12(10):1125-1126, 2013. [Invited]. PDF


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COMMENTARIES / EDITORIALS / BOOK REVIEWS / FOREWORDS / HIGHLIGHTS
Apostolopoulos, VEditorial. Delivery methods to antigen presenting cells: development of new improved vaccines. Molecular Pharmaceutics, 4:1-3, 2007. [Special issue on delivery systems for vaccines] [Invited]

Apostolopoulos, V., Weiner, D. and Gong, J. Editorial. Cancer vaccines - methods for inducing immunity. Expert Review of Vaccines, (Special Focus issue on Cancer Vaccines) 7:861-862, 2008. [Invited. Corresponding author]

Apostolopoulos, VBook Review. Cancer vaccines: challenges and opportunities in translation. Eds. Bots and Obrocea, Informa Healthcare. Expert Review of Vaccines, 8(3):289-291, 2009. [Invited]

Apostolopoulos, VEditorial. Peptide based vaccines - are we choosing the right peptides?. Expert Review of Vaccines, 8(3):259-260, 2009. [Invited]

Apostolopoulos, VForeword. Chemistry vs Biology: Neither exists independently of the other. Proceedings of the 10th Medicinal Chemistry: Drug Discovery and Design Conference, 10:5, 2009. [Invited]

Apostolopoulos, VEditorial. MHC and MHC-like molecules in the design of vaccines. Current Pharmaceutical Design, 15(28):3207-3208, 2009. [Invited]

Apostolopoulos, V. and Weiner, D. Editorial. Development of more efficient and effective DNA vaccines. Expert Review of Vaccines, (Special Focus issue on DNA Vaccines) 8(9):1133-1134, 2009. [Invited. Corresponding author].

Apostolopoulos, VForeword. Exciting advances into Multiple Sclerosis. Proceedings of the 11th Medicinal Chemistry: Drug Discovery and Design Conference, 11:3, 2010. [Invited]

Apostolopoulos, VBook Review. New Generation Vaccines (4th Edition). Eds. Levine MM, Informa Healthcare. Expert Review of Vaccines, 9(6):551-553, 2010. [Invited]

Apostolopoulos, V. and Marincola, F.M. Foreword. Methods to measure vaccine immunity. Expert Review of Vaccines, 9(6):545-546, 2010. [Invited]

Wilkinson, B.L., Day, S., Malins, L.R., Apostolopoulos, V. and Payne, R.J. Highlight. The sweeter the better for glycopeptide cancer vaccines. Chemistry in Australia, Royal Australian Chemical Institute, March issue 2011. [Highlight of our research on the development of MUC1 glycopeptde vaccines]

Apostolopoulos, VForeword. Vaccines in Clinical Trials: Cancer. Expert Review of Vaccines, 10(6):711-712, 2011. [Invited]

Tzakos, A.G., Briasoulis, E., Thalhammer, T., Jager, W. and Apostolopoulos, VEditorial. Novel Oncology Therapeutics: targeted drug delivery for cancer. Journal of Drug Delivery, Volume 2013, Article ID918304, Epub October 2013, [Invited]. PDF

​Stojanovska, L. and Apostolopoulos, V. Trick or treat? Alternative therapies for menopause. The Conversation, Published 13 February 2014, Article No. 18007, 2014. Link




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​  

GUEST EDITOR
BOOK CHAPTERS
Xing, P.X., Apostolopoulos, V., Trapani, J., Prenzoska, J. and McKenzie, I.F.C. Peptide epitopes in breast cancer mucins. In: Antigen and Antibody Engineering in Breast Cancer Diagnosis and Treatment. Ed: RL Corfield, Plenum Press, NY, 353:9-16, 1994. 

Apostolopoulos, V., Pietersz, G.A., Acres, B.A., Osinski, C., Thyme, G., Xing, P.X., Karanikas, V., Vaughan, H.A. Hwang, L., Popovski, V., Lees, C.J., Ong, C.S. and McKenzie, I.F.C. Tumour Immunotherapy against MUC1 expressing tumours using mannan MUC1. Eds: Calvo, Creplin, Magdelenat, John Libey Eurotext. Breast Cancer. Advances in Biology & Therapeutics, 315-320, 1996

Apostolopoulos, V. Peptides and peptide mimetics: can they be used for tumour immunotherapy? In: Bioactive peptides in drug discovery and design: medical aspects. Eds: J. Matsoukas and T. Mavromoustakos, IOS Press, 22:287-298, 1999. [Invited. Corresponding author].

Xing, P.X., Apostolopoulos, V., Karkaloutsos, J. and McKenzie, I.F.C. Monoclonal antibodies to mucin VNTR peptides. In: Glycoprotein Methods and Protocols: The Mucin. Methods in Molecular Biology. Ed: T. Corfield, Humana Press, New Jersey, 125:369-381, 2000.

Apostolopoulos, V., McKenzie, I.F.C. and Pietersz, G.A. Generation of MUC1 cytotoxic T-cells and epitope mapping. In: Glycoprotein Methods and Protocols: The Mucin. Methods in Molecular Biology. Ed: T. Corfield, Humana Press, New Jersey, 125:455-462, 2000. [Invited. Corresponding author].

Apostolopoulos, V., Pietersz, G. McKenzie, I.F.C. Studies of MUC1 peptides. In: Peptide-Based Cancer Vaccines. Medical Intelligence Unit Series. Ed: M.W. Kast, Landes Bioscience, Chapman and Hall, Ch7:106-120, 2000. [Invited. Corresponding author].

Apostolopoulos, V. and Plebanski, M. Unusual interactions between MHC, peptide and the T cell receptor. In: Drug discovery and design: medical aspects. Eds: J. Matsoukas and T. Mavromoustakos, IOS Press, 55:258-266, 2002. [Invited. Corresponding author].

Apostolopoulos, V., Plebanski, M. and McKenzie, I.F.C. Carbohydrate-based Targets and Vehicles for Cancer and Infectious Diseases Vaccines. In: Immunobiology of Carbohydrates. Ed: S. Wong, Landes Bioscience and Kluwer Academic Press. Ch14:292-301, 2003. [Invited. Corresponding author].

Apostolopoulos, V., Lazoura, E. and Yu, M. MHC and MHC-like molecules: structural perspectives for the design of molecular vaccines. In: Multichain immune recognition receptor signaling: from spatiotemporal organization to human disease. Ed: A. Sigalov, Landes Bioscience, in Experimental Medicine and Biology, 640:252-267, 2008. [Invited. Corresponding author].

Katsara, M., Ramsland, PR., Tselios, T., Matsoukas, J. and Apostolopoulos, V. A structural perspective of peptides from myelin basic protein. In: Myelin basic proteins. Ed: J.M Boggs, Nova Science Publishers Inc, Ch5:87-103, 2008. [Invited. Corresponding author].

Lazoura, E., Day, S.L. and Apostolopoulos, V. Applications for peptide-based cancer vaccine design. Frontiers in Medicinal Chemistry, 4(1):541-561, 2009.

Pietersz, G.A., Pouniotis, D.S. and Apostolopoulos, V. Design of peptide-based vaccines for cancer. Frontiers in Medicinal Chemistry, 5:127-166, 2010. 

JOURNAL COVER IMAGES
Journal of Immunology, Volume 162, number 1-6 (issues Jan1, Jan15, Feb1, Feb15, March1 March15) 1999. Structure of MHC Class I in complex with looping out MUC1 peptide. 

Current Medicinal Chemistry, Volume 9, number 4 (February) 2002. Molecular model of MUC1 peptide and MUC1 mimic peptide in complex with MHC class I and TCR. 

Drug Design and Discovery - Medicinal Chemistry Program 1998-2005, University of Patras handbook, 2006. Peptide mimics for cancer immunotherapy – model with MHC and TCR. 

Current Medicinal Chemistry, Volume 13, number 17 (June) 2006. Molecular model of cyclic GnRH analogue. 

Current Medicinal Chemistry, Volume 13, number 19 (August) 2006. Molecular model of cyclo(4-9)[Lys4, D-Trp6, Glu9]GnRH analogue. 

Immunology, Volume 119, number 3 (November) 2006. X-ray crystal structure of low affinity MUC1-8 tumour associated peptide with mutations to enable high affinity binding and enhanced immune responses. 

Molecular Pharmaceutics, Volume 4, number 1 (January/February) 2007. Image of bacterial, viral and microsphere vectors used for gene and protein delivery to antigen presenting cells 

Human Vaccines, Volume 4, number 6 (November/December) 2008. Structure of a non-canonical peptide [a glycopeptide derived from the tumour associated peptide MUC1-8], which utilises the GalNAc residue for high affinity binding. 

European Journal of Immunology, Volume 39, number 1 (January) 2009. Confocal image of tetraspanin deficient DCs. 

Current Pharmaceutical Design, Volume 15, number 28 (October) 2009. Crystal structures of (i) low affinity non-canonical MUC1-8 peptide and (ii) high affinity double mutant MUC1-85F8L peptide in complex with MHC class I, H2Kb. 

European Journal of Immunology, Volume 43, number 5 (May) 2013. Electron micrograph image of CD37 deficient DCs. 
CONFERENCE PROCEEDINGS
McKenzie, I.F.C., Apostolopoulos, V. and Xing, P.X. Immunotherapy for breast cancer with synthetic peptides. Journal of Cellular Biochemistry, supplement, 17D:125-125, 1993. 

McKenzie, I.F.C., Apostolopoulos, V., Xing, P.X. and Pietersz, G.A. Is a breast cancer vaccine feasible. Journal of Leukocyte Biology, supplement, 104-104, 1993

Apostolopoulos, V., Xing, P.X., Pietersz, G.A. and McKenzie, I.F.C. Use of synthetic peptides to immunize against breast cancer. Journal of Leukocyte Biology, supplement, 88-88, 1993. 

McKenzie, I.F.C., Apostolopoulos, V., Xing, P.X., Loveland, B.E. and Pietersz, G.A. The immunogenicity of MUC1 peptides and mannan-fusion protein (M-FP). In: Molecular and Cellular Biology. Journal of Cellular Biochemistry, 21A:173-173, 1995. 

Apostolopoulos, V., Pietersz, G.A., Acres, B. and McKenzie, I.F.C. Mannan MUC1-fusion protein and gene therapy. Cancer Gene Therapy, 123, 2:299-299, 1995. [Nature publishing group] 

McKenzie, I.F.C., Apostolopoulos, V., Yu, M. and Wilson, I.A. Structural features of peptides binding MHC class I molecules. Immunology and Cell Biology, 78(4):A14, 2000. [Nature publishing group]. 

Apostolopoulos, V., Yu, M., Pietersz, G.A., Li, W., Teyton, L., McKenzie, I.F.C. and Wilson, I.A. Crystal structures of non-canonical binding peptides: Low affinity vs high affinity binding. FASEB Journal, 15:A321-A321, 2001. 

Apostolopoulos, V. Crystal structures of non-canonical low and high affinity peptide complexes with MHC class I: a novel use of alternative anchors. Review of Clinical Pharmacology and Pharmacokinetics. International edition, 17:71-72, 2003.

Apostolopoulos, V. Structural and immunological analysis of non-canonical peptide complexes with MHC class I: new approaches to vaccine design. Tissue Antigens, 66:351-351, 2005.

Katsara M,, Tselios T., Deraos S., Deraos G., Matsoukas J. and Apostolopoulos, V. Myelin Basic Protein (MBP) and Proteolipid Protein (PLP) Peptides (linear and cyclic) and immune responses in animal models. Therapeutic Approaches for Multiple Sclerosis. Tissue Antigens, 66:461-461, 2005. 

Tang, CK., Lodding, J., Minigo, G., McKenzie, IFC., Pouniotis, DS., Scholzen, A., Plebanski, M., Pietersz, M and Apostolopoulos, V. Oxidised and reduced mannan as receptor mediated gene delivery vehicles. Tissue Antigens, 66:558-558, 2005. 

Sheng, KC., Pouniotis, DS., Wright, MD, Tang, CK, Pietersz, GA. and Apostolopoulos, V. Mannan derivatives induce phenotypic and functional maturation of mouse dendritic cells. Tissue Antigens, 66:541-542, 2005. 

Pietersz, G,A., Tang, C.K., Sheng, K,C., Maxwell, T., Pouniotis, D.S., Lodding, J., Minigo, G., Plebanski, M., McKenzie, I.F.C., Lopez, A. and Apostolopoulos, V. Mannan-mediated delivery of protein, DNA and RNA to antigen presenting cells. Tissue Antigens, 66:512-512, 2005. 

Pietersz, G,A., Esparon, S., Proudfoot, O., Lodding, J., Singh, Y., Meanger, J., Plebanski, M., Hogarth, M., Coulson, B., Apostolopoulos, V. and Cheers, C. Development of mucosal vaccines for respiratory syncytial virus, bacillus anthracis and rotavirus based on oxidised mannan. Tissue Antigens, 66:512-513, 2005

Pouniotis, D.S., Apostolopoulos, V. and Pietersz, G.A. Mechanism of uptake, processing and class I/II presentation of protein and peptides linked to membrane translocating peptides. Tissue Antigens, 66:515-515, 2005. 

Gartlan, K.H., Nastovska, R., van Spriel, A., Sheng, K.C., Lazoura, E., Robb, G., Pietersz, G.A., Apostolopoulos, V. and Wright, M.D. The immune function of mice deficient for the tetraspanin proteins CD37 and Tssc6. Tissue Antigens, 66:425-425, 2005. 

Maxwell, T., Tang, C.K., Forster, T., Pietersz, G.A.,Apostolopoulos V. and Lopez, J.A. Efficient antigen delivery into dendritic cell by transfection of mRNA conjugated with oxidised-mannan and polyethylenimine. Tissue Antigens, 66:490-490, 2005. 

Wright, M.D., van Spriel, A.B., Gartlan, K., Nastovska, R., Sofi, M., Daunt, C., Sheng, KC., Apostolopoulos V., Pietersz, G.A., Light, A. and Tarlington, D. The role of the tetraspanin CD37 in T and B cell responses. Tissue Antigens, 66:593-593, 2005. 

Deraos G., Katsara M,, Tselios T., Deraos S., Matsoukas J. and Apostolopoulos, V. Design and synthesis of Myelin Basic Protein (MBP) linear and cyclic peptide analogues complexed with mannan: Effects in cytokine production. Journal of Peptide Science, 12:223-223 (Th474), 2006. 

Pietersz, G.A., Pouniotis, D.S. and Apostolopoulos, V. Novel methods of antigen delivery for vaccines. Review of Clinical Pharmacology and Pharmacokinetics, International Edition, 21:106-107, 2007.

Lazoura, E., Lodding, J., Farrugia, W., Ramsland, P.A., Stevens, J., Wilson, I.A., Pietersz, G.A. and Apostolopoulos, V. Crystal structure of the anchor modified non-canonical tumor associated MUC1-8 peptide, showing enhanced MHC class I binding and immune responses, in complex with H-2Kb. Review of Clinical Pharmacology and Pharmacokinetics, International Edition, 21:124-124, 2007.

Katsara, M., Deraos, G., Tselios, T., Deraos, S., Matsoukas, J. and Apostolopoulos, V. Immune responses of the myelin basic protein (MBP83-99) analogues (alone or conjugated with mannan) in SJL/J mice. Review of Clinical Pharmacology and Pharmacokinetics, International Edition, 21:135-136, 2007.

Vassilaros, S., Tsibanis, A., Tsikkinis, A., McKenzie, I. and Apostolopoulos, V. Ten years follow-up of pilot phase III immunotherapy study in early breast cancer patients using oxidized mannan-MUC1. Breast Cancer Research and Treatment, 106:S31-S31, 2007. 

Katsara, M., Deraos, G., Matsoukas, J. and Apostolopoulos, V. T cell receptor altered peptide ligands of Myelin Basic Protein (MBP) and Proteolipid Protein (PLP) peptides (Linear and Cyclic) can modulate immune responses in SJL/J mice: Bioactive peptides for Multiple Sclerosis. Proceedings of the 4th International peptide symposium. Australian Peptide Association, 229:1-3, 2008.

Pouniotis, D.S., Apostolopoulos, V. and Pietersz, G.A. Delivery of tumor antigens using a membrane translocating peptide to dendritic cells induces cellular and protective immune responses. Cancer Immunology Immunotherapy, 57:S1-S53 (P032), 2008

Sheng, K.C., Kalkanidis, M., Pietersz, G.A., Pouniotis, D.S., Esparon, S., Tang, C.K. and Apostolopoulos, V. A novel mannose-based antigen delivery system potentiates immunogenicity via specific DC subtypes and TLR4 functionality. Cancer Immunology Immunotherapy, 57:S1-S53 (P139), 2008. 

Katsara, M., Yuriev, E., Ramsland, P., Deraos, G., Matsoukas, J. and Apostolopoulos, V. Development of a vaccine against Multiple Sclerosis. Journal of Peptide Science, 14, 20-20 (P22100-148), 2008. 

Perret, J., Pouniotis, D.S., McDonald, C. and Apostolopoulos, V. T helper-17 cell responses in chronic obstructive pulmonary disease: A pilot study. Respirology, 13: Supp2: A51, 2008.

Katsara, M., Deraos, G., Matsoukas, J. and Apostolopoulos, V. Towards a vaccine against Multiple Sclerosis. In: 30EPS, Peptides, 2-14-182: 376-377, 2009.

Deraos, G., Chatzantoni, K., Matsoukas, M-T., Katsara, M., Tselios, T., Deraos, S., Papathanasopoulos, P., Vynios, D., Apostolopoulos, V., Mouzaki, A. and Matsoukas, J. Modifications of the myelin basic protein epitope MBP87-99 divert Th2 to Th1: immune responses in PBMC from MS patients. In: 30EPS, Peptides, 2-01-106: 230-231, 2009.

Apostolopoulos, V., Katsara, M., Day, S.D., Tselios, T. and Matsoukas, J. Immunotherapeutic aspects for MS: are we heading in the right direction.?. In: Multiple Sclerosis Journal, 2012. ​


                                                       ________________________ // ________________________

OTHER PUBLICATIONS
Apostolopoulos, V. A vaccine for breast cancer within sight? Inpharma : Views and Reviews, 915:3-4, 1993.
Apostolopoulos, V. Cancer - Mucins - Vaccines and Dynabeads: The Relationship. DYNALogue, 2:3-4, 1996.
Apostolopoulos, V. Cancer and prevention: Where are we. Vita : Views, 35, 1997.
Apostolopoulos, V. Editorial Review. Socrates in New York, Author: John Kotselas, Athena Publications. 1998. LINK
Apostolopoulos, V. and Stojanovska, L. Trick or Treat: Alternative therapies for Menopause. Neos Kosmos, English Edition, Published 24 March 2014. LINK
PATENTS
Inventor on 13 patents
1994, Austin Research Institute
1995, Prof Bruce Acres Visit to Lab
THE LABORATORY OVER THE YEARS
1996, Learning in the Lab
1993, Working or Posing..?
1993, Vasso in the Mouse House
1994, Vasso in Tissue Culture
1991, Research Lab Team
1991, Austin Research Institute
1992, Friends in the Lab
1992, Working hard in the Lab
1994, Vasso in the Lab
1996, Learning in the Lab
1996, Working in Tissue Culture
1996, MUC1 Lab Group
2003, Research Lab Christmas Lunch
1997 Lab Christmas Lunch
1997 ARI Lab Heads Retreat, Queenscliff
1997 Lab Christmas Lunch, Trials Lab
1996, Research Lab Team
1993, Austin Research Institute
2001, Austin Research Institute
2005, Austin Research Institute
2004, Research Laboratory
2001, Data analysis with RA, Ms Carla Osinski
2003, Research Laboratory
1997, Research Lab Team
2005, Research Laboratory
2010, PostDoc Dr Kuo-Ching Sheng
2011, In the Lab
1997, Research Lab Team
Work featured on Journal Covers

Jan-March 1999                   
6 issues                               February 2002                      March 2006                           June 2006
August 2006                          November 2006                   January 2007                       November 2008
 January 2009                         October 2009                         May 2013
Novel Oncology Therapeutics: Targeted Drug Delivery for Cancer

Guest Editors: Tzakos, A.G., Thalhammer, T., Briasoulis, E., Jager, W. and Apostolopoulos, V. 
Journal of Drug Delivery. Special Issue. 12 Articles and 1 Editorial, Published Nov 2012 - Oct 2013, Volume 2013. Link
Special Focus Issue: Cancer Vaccines

Guest Editors: Apostolopoulos, V., Weiner D. and Gong, J. 
Expert Reviews of Vaccines. Volume 7, Number 7, September 2008. Link
Special Focus Issue: DNA Vaccines

Guest Editors: Apostolopoulos, V. and Weiner D. 
Expert Reviews of Vaccines. Volume 8, Number 9, September 2009. Link
Special Focus Issue: Methods for measuring vaccine immunity

Guest Editors: Apostolopoulos, V. and Marincola, F.M.
Expert Reviews of Vaccines. Volume 9, Number 6, September 2010. Link
Ranked in the top 20 from 2010-December 2012 as assessed by BioMedLib (www.BioMedLib.com)
Special Focus Issue: Vaccines in clinical trials: Cancer
Guest Editors: Apostolopoulos, V.
Expert Reviews of Vaccines. Volume 10, Number 6, June 2011. Link
Hot Topic Issue: Structural insights of the MHC molecule in the design of vaccines

Guest Editor: Apostolopoulos, V
Current Pharmaceutical Design. Volume 15, Number 28, October 2009. Link
CLICK ON IMAGE TO GET LINK TO BOOK

1994                             1996                             1999                           2000a                          2000b                          2000
2002                             2003                            2008                           2008                            2009                              2010
COMMENTS
Featured Topic: Antigen Delivery

Guest Editors: Apostolopoulos, V
Molecular Pharmaceutics. Volume 4, Number 1, February 2007. Link


Jan-March 1999                   
6 issues                               February 2002                      March 2006                       June 2006                         August 2006                      November 2006
  February 2007                       November 2008
 January 2009                         October 2009                  May 2013